metabotropic glutamate receptors — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T22641	CDPPB		GluR
	CDPPB is a modulator of mGluR5 positive allosteric(with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5).		GluR
T3483	FTIDC		GluR
	FTIDC is a highly potent and selective allosteric antagonist of mGluR1 receptors and shows very weak potency against human and rat mGluR5 receptors. The inhibition of FTIDC for mGluR1 receptors is shown to be in noncompe...		GluR
T6598	MPEP		GluR
	MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.		GluR
T3482	CFMTI		GluR
	CFMTI is a potent and selective metabotropic glutamate receptor (mGluR) 1 allosteric antagonist (IC50: 2.6 nM). The selectivity of CFMTI to mGluR1 is higher 2000-fold than mGluR5.		GluR
T3477	E4CPG		GluR
	E4CPG is a novel group I/II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG.		GluR
T21747	VU0483605		GluR
	VU0483605 is an effective and selective positive allosteric modulator of mGluR1 with EC50s of 390 and 356 nM for human and rat, respectively.		GluR
T2497	MPEP hydrochloride		GluR
	MPEP hydrochloride is an effective and highly specific non-competitive antagonist at the mGlu5 receptor subtype (IC50: 36 nM).		GluR
T15275	Fenobam		GluR
	Fenobam shows inverse agonist activity which blocks the mGlu5 receptor basal activity(IC50: 84 nM). Fenobam has anxiolytic activity. Fenobam is a selective and non-competitive mGluR5 antagonist acting at an allosteric mo...		GluR
T3464	PHCCC	(-) PHCCC	GluR
	PHCCC ((-) PHCCC) is a Group I metabotropic glutamate receptor antagonist and a positive allosteric modulator of mGluR4. It also is a potent to antagonism for mGluR2 and mGluR8.		GluR
T10573	BMT-145027		GluR
	BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50 = 47 nM).		GluR
T13441	(R)-ADX-47273		GluR
	(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator(EC50 of 168 nM for potentiation ).		GluR
T13321	VU6005649		GluR
	VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).		GluR
T3451	JNJ-42153605		GluR
	JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM).		GluR
T4500	ADX88178		GluR
	ADX88178 is a potent positive allosteric modulator for metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4.		GluR
T6725	VU 0357121		GluR
	VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes.		GluR
T6160	VU 0364439		GluR
	VU 0364439 is a mGlu4 positive allosteric modulator (C50: 19.8 nM).		GluR
T13323	VU6012962		GluR
	VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).		GluR
T8862	ML 254		GluR
	ML254 competitively interacts with the MPEP allosteric binding site. ML254 is highly selective for mGlu5 versus other mGlu receptors, has a clean ancillary Ricerca profile, and suitable dystrophia myotonica protein kinas...		GluR
T6727	VU0364770	VU 0364770	GluR
	VU0364770 (VU 0364770)(EC50=1.1 μM), a positive allosteric modulator(PAM) of mGlu4, shows insignificant activity at 68 other receptors, including other mGlu subtypes.		GluR
T7494	TCN238	TCN 238	GluR
	TCN238 is an orally bioavailable positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4with an EC50 of 1 μM).		GluR